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KMID : 0359720130310030199
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Journal of the Korean Neurological Association
2013 Volume.31 No. 3 p.199 ~ p.202
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Epstein-Barr Virus Brainstem Encephalitis With Anti-N-methyl-D-aspartate Receptor Antibodies
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Lim Jung-Ah
Byun Jung-Ick
Lee Soon-Tae
Jung Keun-Hwa
Kim Young-Soo
Kim Jeong-Min
Lee Sang-Kun
Chu Kon
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Abstract
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The neurological manifestations caused by Epstein-Barr virus (EBV) occur only rarely in association with its primary infection or reactivation. The mechanism by which EBV produces neurological disease is unknown. This article describes two cases of polymerase-chain-reaction-proven EBV brainstem encephalitis. The sera of both patients contained autoantibodies against N-methyl-D-aspartate receptor (NMDAR), suggesting the presence of a secondary immunological mechanism. Prospective studies are needed to reveal whether the subgroup of patients with EBV encephalitis and anti-NMDAR antibodies have different clinical presentations and would benefit from immunotherapy. Key Words: Encephalitis, Epstein-Barr virus, N-Methyl-D-aspartate
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KEYWORD
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Encephalitis, Epstein-Barr virus, N-Methyl-D-aspartate
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